Research topics

Particle and heavy ion physics with applications in bio-physics

  • Topic Manager (out of the LMBE): Dr Miloš Đorđević, Associate Research Professor - VNS (010)
  • Associates:
  • Associates from abroad and/or external associates: Dr Ivan Petrović, NSV (010)
    Dr Sebastien Incerti, CENBG, CNRS/IN2P3/Université Bordeaux 1
  • Research Summary:

    Higgs boson physics and top quark physics at LHC and higher energies will be studied. In the further phases of the CMS experiment and on future colliders (FCC, CEPC and others) it is crucial to develop and accelerate algorithms for event reconstruction, where machine learning and GPU programming methods will be applied. These techniques will also be used to accelerate the Geant4-DNA package, as well as to simulate DNA strand breaks due to radiation, as part of a multidisciplinary study of the biophysical effects of radiation at the cellular and subcellular levels, with proton and carbon ion therapy planning. Combining experimental cell irradiation and Geant4-DNA simulation, will provide testing of this tool. Also, the effects of dose distribution, fluence, energy and linear energy transfer of particles will be analyzed. The geometries of DNA double-stranded breaks will also be defined.
  • Projects on the Topic:
    • 2021 - 23 ESA multilateral project EXPRO+ /BioRad3, AO-1-10318.
    • 2014 - .. GEANT4-DNA Collaboration  (coordinated by CENBG since 2008)
    • 2009 - .. GEANT4 Collaboration, Low Energy Electromagnetic Working Group and Advanced Examples Working Group, Organisation Européenne pour la Recherche Nucléaire – CERN, Switzerland.
  • Publications:
    1. M. Scholz, T. Friedrich, G. Magrin, P. Colautti, A. Ristić-Fira, I. Petrović. Characterizing radiation effectiveness in ion beam therapy, Characterizing radiation effectiveness in ion beam therapy, Part I: Introduction and Biophysical Modelling of RBE using the LEMIV, Frontiers in Physics - Medical Physics and Imaging: Applied Nuclear Physics at Accelerators, 2020, 8:272, https://doi.org/10.3389/fphy.2020.00272
    2. Dousatsu Sakata, Oleg Belov, Marie-Claude Bordage, Dimitris Emfietzoglou, Susanna Guatelli, Taku Inaniwa, Vladimir Ivanchenko, Mathieu Karamitros, Ioanna Kyriakou, Nathanael Lampe, Ivan Petrovic, Aleksandra Ristic-Fira, Wook-Geun Shin, Sebastien Incerti. Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and following repair using Geant4-DNA. Scientific Reports, 2020, 10, 20788, https://doi.org/10.1038/s41598-020-75982-x
    3. Ivan M. Petrović, Aleksandra M. Ristić Fira, Otilija D. Keta, Vladana D. Petković, Giada Petringa, Pablo Cirrone, Giacomo Cuttone. A Radiobiological Study of Carbon Ions of Different Linear Energy Transfer in Resistant Human Malignant Cell Lines. International Journal of Radiation Biology, 2020, 96 (11), 1400-1412, https://doi.org/10.1080/09553002.2020.1820609
    4. Otilija Keta, Vladana Petković, Pablo Cirrone, Giada Petringa, Giacomo Cuttone, Dousatsu Sakata, Wook-Geun Shin, Sebastien Incerti, Ivan Petrović and Aleksandra Ristić Fira. DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. International Journal of Radiation Biology, 2021, 97(9), 1229-1240, DOI: 10.1080/09553002.2021.1948140, https://doi.org/10.1080/09553002.2021.1948140
    5. Wook‐Geun Shin, Dousatsu Sakata, Nathanael Lampe, Oleg Belov, Ngoc Hoang Tran, Ivan Petrovic, Aleksandra Ristic‐Fira, Milos Dordevic, Mario A. Bernal, Marie‐Claude Bordage, Ziad Francis, Ioanna Kyriakou, Yann Perrot, Takashi Sasaki, Carmen Villagrasa, Susanna Guatelli, Vincent Breton, Dimitris Emfietzoglou and Sebastien Incerti. A Geant4‐DNA Evaluation of Radiation‐Induced DNA Damage on a Human Fibroblast. Cancers 2021, 13, 4940. https://doi.org/10.3390/cancers13194940
  • Cooperations:

    Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Katanija, Italija

    Centre national de la recherche scientifique (CNRS), France and consortium of European institutions