Istraživačke teme

Fizika čestica i teških jona sa primenama u biofizici

  • Rukovodilac teme (van LMBE): Dr Miloš Đorđević, VNS (010)
  • Saradnici:
  • Saradnici iz inostranstava i/ili spoljni saradnici: Dr Ivan Petrović, NSV (010)
    Dr Sebastien Incerti, CENBG, CNRS/IN2P3/Université Bordeaux 1
  • Sažetak istraživanja:

    Proučavaće se fizika Higgs bozona i fizika top kvarka na LHC i višim energijama. U daljim fazama rada eksperimenta CMS i na budućim sudaračima (FCC, CEPC i drugim) od ključnog značaja je razvoj i ubrzanje algoritama za rekonstrukciju dogadjaja, gde ce biti primenjene metode masinskog ucenja i GPU programiranja. Te tehnike bice upotrebljene i za ubrzavanje Geant4-DNA paketa, kao i za simulaciju prekida DNK lanaca usled zračenja, u okviru multidisciplinarnog istraživanja biofizičkih efekata zračenja na ćelijskom i subćelijskom nivou, sa primenom u planiranju terapije maligniteta protonima i jonima ugljenika. Kombinovanjem eksperimentalnog ozračivanja ćelija i Geant4-DNA simulacija proverava se ovaj alat i analiziraju efekti raspodele doze, fluensa, energije i linearnog transfera energije čestica. Definisaće se i geometrije dvolančanih prekida DNK.
  • Projekti na temi:
    • 2021 - 23 ESA multilateralan projekat EXPRO+ /BioRad3, AO-1-10318.
    • 2014 - ... GEANT4-DNA kolaboracija (koordinisana od strane CENBG оd 2008. godine)
    • 2009 - ... GEANT4 kolaboracija, Low Energy Electromagnetic Working Group i Advanced Examples Working Group, Organisation Européenne pour la Recherche Nucléaire – CERN, Švajcarska.
  • Publikacije:
    1. M. Scholz, T. Friedrich, G. Magrin, P. Colautti, A. Ristić-Fira, I. Petrović. Characterizing radiation effectiveness in ion beam therapy, Characterizing radiation effectiveness in ion beam therapy, Part I: Introduction and Biophysical Modelling of RBE using the LEMIV, Frontiers in Physics - Medical Physics and Imaging: Applied Nuclear Physics at Accelerators, 2020, 8:272, https://doi.org/10.3389/fphy.2020.00272
    2. Dousatsu Sakata, Oleg Belov, Marie-Claude Bordage, Dimitris Emfietzoglou, Susanna Guatelli, Taku Inaniwa, Vladimir Ivanchenko, Mathieu Karamitros, Ioanna Kyriakou, Nathanael Lampe, Ivan Petrovic, Aleksandra Ristic-Fira, Wook-Geun Shin, Sebastien Incerti. Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and following repair using Geant4-DNA. Scientific Reports, 2020, 10, 20788, https://doi.org/10.1038/s41598-020-75982-x
    3. Ivan M. Petrović, Aleksandra M. Ristić Fira, Otilija D. Keta, Vladana D. Petković, Giada Petringa, Pablo Cirrone, Giacomo Cuttone. A Radiobiological Study of Carbon Ions of Different Linear Energy Transfer in Resistant Human Malignant Cell Lines. International Journal of Radiation Biology, 2020, 96 (11), 1400-1412, https://doi.org/10.1080/09553002.2020.1820609
    4. Otilija Keta, Vladana Petković, Pablo Cirrone, Giada Petringa, Giacomo Cuttone, Dousatsu Sakata, Wook-Geun Shin, Sebastien Incerti, Ivan Petrović and Aleksandra Ristić Fira. DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. International Journal of Radiation Biology, 2021, 97(9), 1229-1240, DOI: 10.1080/09553002.2021.1948140, https://doi.org/10.1080/09553002.2021.1948140
    5. Wook‐Geun Shin, Dousatsu Sakata, Nathanael Lampe, Oleg Belov, Ngoc Hoang Tran, Ivan Petrovic, Aleksandra Ristic‐Fira, Milos Dordevic, Mario A. Bernal, Marie‐Claude Bordage, Ziad Francis, Ioanna Kyriakou, Yann Perrot, Takashi Sasaki, Carmen Villagrasa, Susanna Guatelli, Vincent Breton, Dimitris Emfietzoglou and Sebastien Incerti. A Geant4‐DNA Evaluation of Radiation‐Induced DNA Damage on a Human Fibroblast. Cancers 2021, 13, 4940. https://doi.org/10.3390/cancers13194940
  • Saradnje:

    Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Katanija, Italija

    Centre national de la recherche scientifique (CNRS), Francuska i konzorcijum instituta iz Evrope