Otilija Keta - Laboratorija za molekularnu biologiju i endokrinologiju

Istraživanja

research associate

E-mail: otilijak@vin.bg.ac.rs

Phone: +381 11 3408 743

ORCID: 0000-0003-4974-8741

Projects where the researcher is engaged

Biophysical study of the effects induced by carbon ion beams and secondary particles produced by nuclear fragmentation (Grande Rilevanza Project (MAECI – Ministero degli Affari Esteri e della Cooperazione Internationale, Italy)
ENSAR2 (European Nuclear Science and Applications Research2), Networking Activities (NAs) and Transnational Access Activities (TNAs) (Grant Agreement number 654002-ENSAR2, 2015 i dalje)
FP7 - Project within European Commission (EC), ENSAR (European Nuclear Science and Applications Research) through Transnational Access Activities (TNAs) – TNA03 INFN–LNL–LNS (Grant Agreement number 262010, 2011-2014)
HADMAC – Hadrons with Malignant Cells (Project with INFN-LNS)
Particle and heavy ion physics with applications in bio-physics
Radiation biology of the cell: application in therapy and protection
Radiosenzitivnost humanog genoma, OI173046
Validation of the GEANT4-DNA Simulation Code by Quantification of Early DNA Damages Induced by Ionizing Radiation - G4DNAQuanti

PhD: Faculty of Biology, University of Belgrade, 2014.

Title: „In vitro studija nesitnoćelijskog arcinoma pluća: efekat jonizujućeg zračenja i inhibitora tirozin-kinazne aktivnosti receptora za epidermalni faktor rasta“

BSc: Biology, Faculty of Biology, University of Belgrade, 2007.

Professional training

2008. Radiobiological Studies of Human Malignant Cells with 62 MeV/u 1H and 12C Ions (INFN-LNS).

2013.-2014. Hadrons with malignant cells - HADMAC (European Commission - EC, ENSAR - European Nuclear Science and Applications Research, Transnational Access Activities - TNAs / TNA03 INFN–LNL–LNS, Grant Agreement: n° 262010).
Research fields

Cancer cell biology; cellular radiobiology

Selected publications

Keta O, Petković V, Cirrone P, Petringa G, Cuttone G, Sakata D, Shin WG, Incerti S, Petrović I, Ristić Fira A. DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. Int J Radiat Biol. 2021;97(9):1229-1240. doi: 10.1080/09553002.2021.1948140. Epub 2021 Jul 19. PMID: 34187289.

Keta OD, Todorović DV, Bulat TM, Cirrone PG, Romano F, Cuttone G, Petrović IM, Ristić Fira AM. Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. Exp Biol Med (Maywood). 2017 May;242(10):1015-1024. doi: 10.1177/1535370216669611. Epub 2016 Sep 15. PMID: 27633574; PMCID: PMC5444635.

Keta O, Bulat T, Golić I, Incerti S, Korać A, Petrović I, Ristić-Fira A. The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to γ-rays and/or erlotinib. Cell Biol Toxicol. 2016 Apr;32(2):83-101. doi: 10.1007/s10565-016-9319-z. Epub 2016 Mar 29. PMID: 27026538.

Petrović IM, Ristić Fira AM, Keta OD, Petković VD, Petringa G, Cirrone P, Cuttone G. A radiobiological study of carbon ions of different linear energy transfer in resistant human malignant cell lines. Int J Radiat Biol. 2020 Nov;96(11):1400-1412. doi: 10.1080/09553002.2020.1820609. Epub 2020 Oct 1. PMID: 32910708.

Petković VD, Keta OD, Vidosavljević MZ, Incerti S, Ristić Fira AM, Petrović IM. Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. Int J Radiat Biol. 2019 Mar;95(3):274-285. doi: 10.1080/09553002.2019.1549753. Epub 2019 Jan 22. PMID: 30451568.