Research topics

Redox signaling is a key factor in the regulation of molecular mechanisms of many physiological / pathological conditions. During physiological aging and in pathological conditions and tumors, oxidative stress may lead to changes in biomolecules. Hence, the identification and characterization of specific redox-regulated signaling pathways is the main goal of the research. Tumor cells are often in a hypoxic environment that affects metabolism, proliferation, metastasis, apoptosis, angiogenesis, and the immune response. The understanding of redox regulation enables the development of new clinical approaches. This strategy includes the development of molecules that specifically target certain "switches" and disregulated redox signaling cascades / production of reactive oxygen species, so part of the research is devoted to the potential use of nanoparticles. Lipidomics aims to identify / determine all lipid species in the biological system and determine the role of these molecules in physiological / pathological conditions. Lipids play a key role in maintaining energy balance, regulating membrane dynamics and signal transduction, changes in the concentration / function of certain lipid classes / species could precede the onset of the disease, which allows the discovery of predictive lipid markers. Lipidomic studies of various diseases in humans and animal models are planned. New knowledge about the role of metabolic and signaling pathways of lipids in these diseases will contribute to a better understanding of their etiology and enable new therapeutic directions. The effect of antipsychotics on the parameters of oxidative stress and the level of monoamines in the central nervous system, as well as the sympathetic nervous system in chronic stress, will also be examined. Part of the research will be related to the field of nutrigenomics, that is, the role of antioxidants as bioactive components on gene expression.