Research topics

Modern humanity is affected by a pandemic of metabolic disorders based on insulin resistance. It is believed that the causes of this phenomenon lie in the way of life of modern man. Bad habits related to high-calorie diet and reduced physical activity, as well as ubiquitous stress, encourage the development of metabolic disorders, which are closely related to cardiovascular diseases. In light of these data, research on the topic has focused on the molecular mechanisms of action of insulin, as well as the molecular basis of the genesis of insulin resistance and metabolic syndrome. Specifically, the action of insulin in the regulation of energy metabolism, ion transport, heart contraction, nitrogen monoxide production, the occurrence of inflammation in the heart is analyzed. Other tissues in which insulin exerts significant metabolic effects, such as the liver and adipose tissue, are also of potential importance. Research is being conducted on animal models of human metabolic pathologies. Fructose-rich diets are primarily used to create animal models of insulin resistance and metabolic syndrome.

Current research primarily examines non-pharmacological approaches in the prevention and treatment of metabolic disorders, such as physical activity and various dietary regimes (functional foods and dietary supplements - vitamins, antioxidants, etc.). The role of sex, ie sex steroid hormones, in the genesis of metabolic disorders is also analyzed. Research, in addition to the basic aspect, has a strong translational potential, and the results can be useful to professionals dealing with metabolic disorders in the field of human or veterinary medicine from various aspects.