Survivors of COVID19: variety of immune responses to SARS-CoV-2 in correlation with clinical manifestation. Long term follow up (Broj projekta 7551587) (2021-2022)

The exact long-term clinical manifestations and etiopathophysiological mechanisms of SARS-Cov-2 infection are still matter of controversy. This study aims to evaluate IgM and IgG levels in recovered COVID19 patients that could indicate the scale of their infectiousness and resistance to reinfection. Further, the correlation of patients ABO blood types with clinical and biochemical markers will improve the understanding of disease incidence, development and complications, including post-infection fibrotic tissue development. By estimating indicators of erythrocytes hemolysis, Project will test the hypothesis that SARS-CoV-2 attacks heme, causing early hypoxia that leads to respiratory distress and blood coagulation disorder. Project results will gain new insights into clinical and molecular characteristics of disease, providing recommendations on the future COVID19 vaccination, and selection of potential convalescent plasma donors. If presented hypothesis of the virus effect on hemoglobin proves to be correct, Project results will lead to recommendations to change the current clinical practice in the treatment of COVID19 patients.